Publications | 박근홍교수연구실 나노재생의학연구실

<2024>

* Lee S, Kim HJ, Choi JH, Jang HJ, Cho HB, Kim HR, Park JI, Park KS, Park KH*. Light emitting diode (LED) irradiation of liposomes enhances drug encapsulation and delivery for improved cancer eradication. J Control Release. 2024 Apr;368:756-767. doi: 10.1016/j.jconrel.2024.03.027. Epub 2024 Mar 20. PMID: 38499090.

* Choi SH, Cho HB, Choi JH, Kim HJ, Jang HJ, Cho S, Maeng E, Park H, Ryu KS, Park KH*, Park KS. Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells. J Control Release. 2024 Feb 13;367:768-778. doi: 10.1016/j.jconrel.2024.02.008.

* Kim HJ, Cho HB, Kim HR, Lee S, Park JI, Park KH*. Upconverting-photon quenching-mediated perforation influx as an intracellular delivery method using posAuNP@UCNPs nanocomposites for osteoarthritis treatment. Nano Converg. 2024 Jan 3;11(1):1. doi:10.1186/s40580-023-00409-y.

<2023>

* Kim HR, Cho HB, Lee S, Park JI, Kim HJ*, Park KH*. Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy Biomater. 2023 302:122350.

* Cho HB, Kim HJ, Kim HR, Lee S, Park JI, Park KH*. Reduction of nanoparticle size and promotion of cell membrane permeability by LED irradiation. Mater. Today Nano 2023 24:100397.

* Cho HB, Kim HJ, Kim HR, Lee S, Park JI, Park KH*. Led-mediated instantaneous pore formation in membranes driven by structural transformation and deprotonation of phospholipids. Chem. Eng. J. 2023 473(2):145269.

* Lee S, Kim HJ, Cho HB, Kim HR, Lee S, Park JI, Park KH*. Melatonin-loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process. Biomater Sci. 2023 Apr 11;11(8):2912-2923.

<2022>

* Kim HJ, Cho HB, Lee S, Lyu J, Kim HR, Lee S, Park JI, Park KH*. Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair. Theranostics. 2022 Aug 29;12(14):6409-6421. Inside Front Cover

* Choi SH, Kim HJ, Park JD, Ko ES, Lee M, Lee DK, Choi JH, Jang HJ, Kim I, Jung HY, Park KH*, Park KS*. Chemical priming of natural killer cells with branched polyethyleneimine for cancer immunotherapy. J Immunother Cancer. 2022 Aug;10(8):e004964.

* Kim HJ, Park JM, Lee S, Cho HB, Park JI, Kim JH, Park JS*, Park KH*. Efficient CRISPR-Cas9-based knockdown of RUNX2 to induce chondrogenic differentiation of stem cells. Biomater Sci. 2022 Jan 18;10(2):514-523.

<2021>

* Lee OH, Lee S, Park M, Moon S, Hwang S, Kim B, Kim CY, Lee DR, Shim SH, Park KH*, Chung HM*, Choi Y*. Generation of a B2M homozygous knockout human somatic cell nuclear transfer-derived embryonic stem cell line using the CRISPR/Cas9 system. Stem Cell Res. 2021 Dec 27;59:102643.

* Lee S, Kim HJ, Park JI, Cho HB, Park JS*, Park KH*. Organelle targeting using a fluorescent probe that selectively penetrates the zona pellucida. Int J Pharm. 2021 Dec 15;610:121282.

* Kim HJ, Lee S, Park JM, Cho HB, Park JI, Park JS*, Park KH*. Development of a three-layer consecutive gene delivery system for enhanced bone regeneration. Biomaterials. 2021 Oct; 277, 121104.

* Park SW, Do HJ, Choi W, Lim DS, Park KH*, Kim JH*. Epithelium-specific ETS transcription factor-1 regulates NANOG expression and inhibits NANOG-induced proliferation of human embryonic carcinoma cells. Biochimie. 2021 Jul;186:33-42.

* Kim HJ, Park JM, Lee S, Hong SJ, Park JI, Lee MS, Yang HS, Park JS, Park KH*. In situ pocket-type microcarrier (PMc) as a therapeutic composite: Regeneration of cartilage with stem cells, genes, and drugs. J Control Release. 2021 Apr 10;332:337-345.

* Kim HJ, Lee S, Lee JH, Park JM, Hong SJ, Lee OH, Park JS, Choi Y, Park KH*. TRITC-Loaded PLGA Nanoparticles as Drug Delivery Carriers in Mouse Oocytes and Embryos. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):5975-5988.

* Kim HJ, Hong SJ, Lee SJ, Park JM, Park JI, Park JS, Shim SH, Park KH*. Induction of Bone Formation by 3D Biologically Active Scaffolds Containing RGD‐NPs, BMP2, and NtMPCs. Adv. Ther. 2021 Jan. 4(4): 2000245.

<~2020>
* 65. Song H, Park KH. Regulation and function of SOX9 during cartilage development and regeneration. Semin Cancer Biol. 2020 Dec;67(Pt 1):12-23.

* 64. Kim HJ, Lee JS, Park JM, Lee S, Hong SJ, Park JS, Park KH. Fabrication of Nanocomposites Complexed with Gold Nanoparticles on Polyaniline and Application to Their Nerve Regeneration. ACS Appl Mater Interfaces. 2020 Jul 8;12(27):30750-30760.

* 63. Kim HJ, Park JS , Yi SW , Go M , Kim HR , Lee SJ , Park JM , Cha DH , Shim SH , Park KH . A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice. Biomater Sci. 2020 Jun 21;8(12):3392-3403.

* 62. Kim HJ, Oh HJ, Park JS, Lee JS, Kim JH, Park KH. Direct Conversion of Human Dermal Fibroblasts into Cardiomyocyte-Like Cells Using CiCMC Nanogels Coupled with Cardiac Transcription Factors and a Nucleoside Drug. Adv Sci (Weinh). 2020 Feb 7;7(7):1901818.

* 61. Yi SW, Park JS, Kim HJ, Lee JS, Woo DG, Park KH. Multiply clustered gold-based nanoparticles complexed with exogenous pDNA achieve prolonged gene expression in stem cells. Theranostics. 2019 Jul 9; 9(17): 5009-5019.

*60.Kim SM, Yi SW, Kim HJ, Park JS, Kim JH, Park KH. Co-Delivery of RUNX2-Targeting miRNAs and shRNAs Using Nanoparticles Composed of Dexamethasone and PEI Induces Chondrogenesis of Human Mesenchymal Stem Cells.J Biomed Nanotechnol. 2019 Jan 1;15(1):113-126.

*59. Yi SW, Kim HJ, Oh HJ, Shin H, Lee JS, Park JS, Park KH. Gene expression profiling of chondrogenic differentiation by dexamethasone-conjugated polyethyleneimine with SOX trio genes in stem cells. Stem Cell Res Ther. 2018 Dec 7;9(1):341.

*58. Park JS, Yi SW, Kim HJ, Oh HJ, Lee JS, Go M, Shim SH, Park K H. Verification of Long-Term Genetic Stability of hMSCs during Subculture after Internalization of Sunflower-Type Nanoparticles (SF-NPs).Theranostics. 2018 Nov 5;8(20):5548-5561.

*57. Kim YS, Park JS, Park M, Ko MY, Yi SW, Yoon JA, Yang S, Shim SH, Park KH, Song H. PLGA nanoparticles with multiple modes are a biologically safe nanocarrier for mammalian development and their offspring. Biomaterials. 2018 Nov;183:43-53.

*56. Kim HJ, Yi SW, Oh HJ, Lee JS, Park JS, Park KH. Transfection of gene regulation nanoparticles complexed with pDNA and shRNA controls multilineage differentiation of hMSCs. Biomaterials. 2018 Sep;177:1-13.

*55. Kim HJ, Park JS, Yi SW, Oh HJ, Kim JH, Park KH, Sequential transfection of RUNX2/SP7 and ATF4 coated onto dexamethasone-loaded nanospheres enhances osteogenesis. Sci Rep. 2018 Jan 23;8(1):1447.

*54. Park JS, Park WR, Park SJ, Larson AC, Kim DH, Park KH, Multimodal Magnetic Nanoclusters for Gene Delivery, Directed Migration, and Tracking of Stem Cells. Adv. Funct. Mater. 2017;27(25):1700396

*53. Park JS, Park W, Kang AY, Larson AC, Kim DH, Park KH. Multi-functional nanotracers for image-guided stem cell gene therapy. Nanoscale. 2017;9(14):4665-4676. Cover

*52. Park JS, Yi SW, Kim HJ, Kim SM, Kim JH, Park KH. Construction of PLGA Nanoparticles coated polycistronic SOX5, SOX6, SOX9 genes for chondrogenesis of human mesenchymal stem cells. ACS Appl. Mater. Interfaces. 2017;18(9):1361-1372.

*51. Han MH, Park SW, Do HJ, Chung HJ, Song H, Kim JH, Kim NH, Park KH, Kim JH. Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells. Biol Pharm Bull. 2016;39(11):1802-1808.

*50. Park JS, Yi SW, Kim HJ, Kim SM, Park KH. Regulation of Cell Signaling Factors Using PLGA Nanoparticles Coated/Loaded with Genes and Proteins for Osteogenesis of Human Mesenchymal Stem Cells. ACS Appl Mater Interfaces. 2016 Nov 9;8(44):30387-30397. Epub 2016 Oct 28.

*49. Kim YM, Potta T, Park KH, Song SC Temperature responsive chemical crosslinkable UV pretreated hydrogel for application to

injectable tissue regeneration system via differentiations of encapsulated hMSCs. Biomaterials. 2017 Jan;112:248-256.

*48. Park JS, Lim HJ, Yi SW, Park KH. Stem cell differentiation-related protein-loaded PLGA microspheres as a novel platform micro-typed scaffold for chondrogenesis. Biomed Mater. 2016 Sep 2;11(5):055003.

*47. Park JS, Park KH. Light enhanced bone regeneration in an athymic nude mouse implanted with mesenchymal stem cells embedded in PLGA microspheres.Biomater Res. 2016 Feb 18;20:4.

*46. Park JS, Yi SW, Kim HJ, Kim SM, Shim SH, Park KH. Sunflower-type nanogels carrying a quantum dot nanoprobe for both superior gene delivery efficacy and tracing of human mesenchymal stem cells.Biomaterials. 2016 Jan;77:14-25.

*45. Park JS, Yi SW, Kim HJ, Park KH. Receptor-mediated gene delivery into human mesenchymal stem cells using hyaluronic acid-shielded polyethylenimine/pDNA nanogels. Carbohydr Polym. 2016 Jan 20;136:791-802.

*44. Park JS, Yang HN, Yi SW, Kim JH, Park KH. Neoangiogenesis of human mesenchymal stem cells transfected with peptide-loaded and gene-coated PLGA nanoparticles. Biomaterials. 2016 Jan;76:226-37.

*43.Park SJ, Park JS, Yang HN, Yi SW, Kim CH, Park KH. Neurogenesis Is Induced by Electrical Stimulation of Human Mesenchymal Stem Cells Co-Cultured With Mature Neuronal Cells. Macromol Biosci. 2015 Nov;15(11):1586-94. BMC Neurosci. 2015 Apr 21;16:23.

42. Shin KS, Zhao TT, Park KH, Park HJ, Hwang BY, Lee CK, Lee MK. Gypenosides attenuate the development of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rat model of Parkinson's disease.

*41. Yang HN, Park JS, Jeon SY, Park KH. Carboxymethylcellulose (CMC) formed nanogels with branched poly(ethyleneimine) (bPEI) for inhibition of cytotoxicity in human MSCs as a gene delivery vehicles Carbohydr Polym. 2015 May 20;122:265-75.

*40. Park HJ, Zhao TT, Lee KS, Lee SH, Shin KS, Park KH, Choi HS, Lee MK. Effects of (-)-sesamin on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and dopaminergic neuronal cells of Parkinson's disease rat models. Neurochem Int. 2015 Apr-May;83-84:19-27.

*39. Yang HN, Park JS, Jeon SY, Park W, Na K, Park KH. The effect of quantum dot size and poly(ethylenimine) coating on the efficiency of gene delivery into human mesenchymal stem cells.. Biomaterials. 2014 Sep;35(29):8439-49

*38. Park SW, Do HJ, Ha WT, Han MH, Park KH, Song H, Kim NH, Kim JH.Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic carcinoma cells. FEBS Lett. 2014 Aug 25;588(17):3129-36.

*37. Jeon SY, Park JS, Yang HN, Lim HJ, Yi SW, Park H, Park KH. Co-delivery of Cbfa-1-targeting siRNA and SOX9 protein using PLGA nanoparticles to induce chondrogenesis of human mesenchymal stem cells. Biomaterials. 2014 Sep;35(28):8236-48

*36. Park W, Yang HN, Ling D, Yim H, Kim KS, Hyeon T, Na K, Park KH. Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking. Biomaterials. 2014 Aug;35(25):7239-47

*35. Yang HN, Choi JH, Park JS, Jeon SY, Park KD, Park KH. Differentiation of endothelial progenitor cells into endothelial cells by heparin-modified supramolecular pluronic nanogels encapsulating bFGF and complexed with VEGF165 genes. Biomaterials. 2014 May;35(16):4716-28.

*34. Jung H, Park JS, Yeom J, Selvapalam N, Park KM, Oh K, Yang JA, Park KH, Hahn SK, Kim K.3D tissue engineered supramolecular hydrogels for controlled chondrogenesis of human mesenchymal stem cells. Biomacromolecules. 2014 Mar 10;15(3):707-14.

*33. Jeon SY, Park JS, Yang HN, Woo DG, Park KH. Aggrecan- and COMP-loaded poly-(lactic-co-glycolic acid) nanoparticles stimulate chondrogenic differentiation of human mesenchymal stem cells. Stem Cells Dev. 2014 Feb 1;23(3):305-17.

*32. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. Poly(N-isopropylacrylamide-co-acrylic acid) nanogels for tracing and delivering genes to human mesenchymal stem cells. Biomaterials. 2013 Nov;34(34):8819-34.

*31. Choi WY, Jeon HG, Chung Y, Lim JJ, Shin DH, Kim JM, Ki BS, Song SH, Choi SJ, Park KH, Shim SH, Moon J, Jung SJ, Kang HM, Park S, Chung HM, Ko JJ, Cha KY, Yoon TK, Kim H, Lee DR. Isolation and characterization of novel, highly proliferative human CD34/CD73-double-positive testis-derived stem cells for cell therapy. Stem Cells Dev. 2013 Aug 1;22(15):2158-73.

*30. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. Multilineage differentiation of human-derived dermal fibroblasts transfected with genes coated on PLGA nanoparticles plus growth factors. Biomaterials. 2013 Jan;34(2):582-97.

*29. Yang HN, Park JS, Woo DG, Jeon SY, Park KH. Transfection of VEGF165 genes into endothelial progenitor cells and bioimaging in vivo using quantum dot nanoparticles in an ischemia hind limb model. Biomaterials 2012;33(33):8670-84.

*28. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis. Biomaterials 2012;33(33):8600-12.

*27. Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, Lim HY, Kim JH, Park KH. Exogenous Nurr1 gene expression in electrically-stimulated human mesenchymal stem cells induces neurogenesis. Biomaterials 2012;33(29):7300-7308.

*26. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. SOX9 gene plus heparinized TGF-b 3 coated dexamethasone loaded PLGA microspheres for inducement of chondrogenesis of hMSCs. Biomaterials 2012;33(29):7151-7163.

*25. Jeon SY, Park JS, Yang HN, Woo DG, Park KH. Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials. 2012;33(17):4413-23.

24. Park KM, Yang JA, Jung H, Yeom J, Park JS, Park KH, Hoffman AS, Hahn SK, Kim K. In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering. ACS Nano. 2012;6(4):2960-8.

*23. Park JS, Shim MS, Shim SH, Yang HN, Jeon SY, Woo DG, Lee DR, Yoon TK, Park KH. Chondrogenic potential of stem cells derived from amniotic fluid, adipose tissue, or bone marrow encapsulated in fibrin gels containing TGF-β3. Biomaterials 2011 Nov;32(32): 8139-49.

*22. Yang HN, Park JS, Woo DG, Jeon SY, Do HJ, Lim HY, Kim JH, Park KH. Chondrogenesis of mesenchymal stem cells and dedifferentiated chondrocytes by transfection with SOX Trio genes. Biomaterials 2011 Oct;32(30):7695-704.

*21. Kim MJ, Park JS, Kim S, Moon SH, Yang HN, Park KH. Encapsulation of Bone Morphogenic Protein-2 with Cbfa1-Overexpressing Osteogenic Cells Derived from Human Embryonic Stem Cells in Hydrogel Accelerates Bone Tissue Regeneration. Stem Cells Dev 2011 Aug;20(8):1349-58.

*20. Yang HN, Park JS, Woo DG, Jeon SY, Do HJ, Lim HY, Kim JH, Park KH. C/EBP-α and C/EBP-β-mediated adipogenesis of human mesenchymal stem cells (hMSCs) using PLGA nanoparticles complexed with poly(ethyleneimmine). Biomaterials 2011 Sep;32(25):5924-33.

*19. Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, Lim HY, Kim JH, Park KH. Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles. Biomaterials 2011 May;32(14):3679-88.

*18. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. Chondrogenesis of human mesenchymal stem cells in fibrin constructs evaluated in vitro and in nude mouse and rabbit defects models. Biomaterials 2011;32(6):1495-507.

*17. Kim JH, Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, Lim HY, Kim JM, Park KH. The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce chondrogenesis. Biomaterials 2011;32(1):268-78.

*16. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. The promotion of chondrogenesis, osteogenesis, and adipogenesis of human mesenchymal stem cells by multiple growth factors incorporated into nanosphere-coated microspheres. Biomaterials 2011;32(1):28-38.

*15. Park JS, Yang HN, Jeon SY, Woo DG, Na K, Park KH. Multi-lineage differentiation of hMSCs encapsulated in thermo-reversible hydrogel using a co-culture system with differentiated cells. Biomaterials 2010;31(28):7275-87.

*14. Park JS, Yang HN, Jeon SY, Woo DG, Na K, Park KH. Osteogenic differentiation of human mesenchymal stem cells using RGD-modified BMP-2 coated microspheres. Biomaterials 2010;31(24):6239-48

*13. Ji Sun Park, Dae Gyun Woo, Han Na Yang, Hye Jin Lim, Kyong Mi Park, Kun Na, Keun-Hong Park. Chondrogenesis of human mesenchymal stem cells encapsulated in a hydrogel construct: Neocartilage formation in an animal models as both mice and rabbits. J Biomed Mater Res A. 2010;92(3):988-96.

*12. Ji Sun Park, Hyun Jung Yang, Dae Gyun Woo, Han Na Yang, Kun Na and Keun-Hong Park. Chondrogenic differentiation of mesenchymal stem cells embedded in a scaffold by long-term release of TGF-b 3 complexed with chondroitin sulfate. J Biomed Mater Res A. 2010;92(2):806-16.

*11. Ji Sun Park, Dae Gyun Woo, Han Na Yang, Jung Mo Kim, Jae Whan Kim, Hyung-Min Chung, Keun-Hong Park. Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells.Biomaterials 2010;31:124-132

*10. Park KH, Kim H, Na K. Neuronal Differentiation of PC12 Cells Cultured on Growth Factor-Loaded Nanoparticles Coated on PLGA Microspheres. J Microbiol Biotechnol. 2009;19(11):1490-5.

*9. Chang Ju Jeon, Hye Jin Lim, Jang Won Kim, Ki Hyeon Hong, Soo-Chang Song, Keun-Hong Park The Use of Injectable, Thermosensitive Poly(organophosphazene)-RGD Conjugates for the Enhancement of Mesenchymal Stem Cell Osteogenic Differentiation. Biomaterials 2009;31:6295-308

*8. Han Na Yang, Ji Sun Park, Dae Gyun Woo, Young Do Kwon, Keun-Hong Park. The use of green fluorescence gene (GFP)-modified rabbit mesenchymal stem cells (rMSCs) co-cultured with chondorcytes in hydrogel constructs to reveal the chondrogenesis of MSCs. Biomaterials 2009;31:6374-85

*7. Dae Gyun Woo, Myung-Sun Shim, Ji Sun Park, Han Na Yang, Dong Ryul Lee, Keun-Hong Park. The effect of electrical stimulation on the differentiation of hESCs adhered onto fibronectin-coated gold nanoparticles.Biomaterials 2009;29:5631-8.

*6. Keun-Hong Park, Hyemin Kim, Sumi Moon, and Kun Na. Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering. Journal of Bioscience and Bioengineering 2009;108(6):530-7.

*5. Keun-Hong Park, Uram Park, and Kun Na. Synthetic matrix containing glucorcoticoid and growth factor for chondrogenic differentiation of stem cells. Journal of Bioscience and Bioengineering 2009;108(2):168-73

*4. Ji Sun Park, , Kun Na, Dae Gyun Woo, Han Na Yang, Keun-Hong Park. Determination of dual delivery for stem cell differentiation using dexamethasone and TGF-beta3 in/on polymeric microspheres. Biomaterials 2009;30(27):4796-805.

*3. JI SUN PARK, HAN NA YANG, DAE GYUN WOO, HYUNG-MIN CHUNG, KEUN-HONG PARK. In vitro and in vivo chondrogenesis of rabbit bone marrow-derived stromal cells in fibrin hydrogel mixed with growth factor loaded in nanoparticles. Tissue Engineering 2009;8:2163-75.

*2. Ji Sun Park, Han Na Yang, dae Gyun Woo, Kun Na, Keun-Hong Park. Transforming growth factor beta-3 bound with sulfate polysaccharide in synthetic extracellular matrix enhanced the biological activities for neocartilage formation in vivo. J Biomed Mater Res A. 2009;91(2):408-15

*1. Keun-Hong Park, Don Haeng Lee, Kun Na. Transplantation of poly(N-isopropylacrylamide-co-vinylimidazole) hydrogel constructs composed of rabbit chondrocytes and growth factor-loaded nanoparticles for neocartilage formation. Biotechnol Lett. 2009;31 (3): 337-343